The Raiders are barred from contact with Smith while he remains on suspension.
Raiders owner Mark Davis has taken a strong stance against cases of domestic violence, saying the team has a "zero-tolerance" policy. If police find reason to believe Smith committed a crime, the team would likely cut ties with Smith soon after.
But even should he come out of this situation free of charges, it has now become increasingly clear that Smith may never see an National Football League field again.
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Duchenne's, a devastating muscle-wasting disease, affects some 15,000 patients in the United States, mostly young boys. By week 52, patients in the Emflaza group maintained an overall stability in average muscle strength.
San Francisco police reportedly are actively reviewing a call early Saturday to Smith's residence.
The Raiders signed him prior to the 2015 season, and he played nine games in silver and black.
Smith has been suspended since November 2016 for multiple violations of the NFL's police on substance abuse.
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With the ninth court of appeals refusing to reinstate the ban, the case is now very likely to head to the US Supreme Court. Trump told a conference of police chiefs that he " heard things he couldn't believe" as he listened to Tuesday's hearing.
Smith filed for reinstatement on October 3 before meeting with commissioner Roger Goodell. His bid to be reinstated has been deferred until March.
If Smith does end up getting arrested it will throw a monkey wrench into his plans to be reinstated by the league. The report was published before the incident in San Francisco. But after serving a nine-game suspension in 2014, Smith was arrested for a third DUI after crashing his auto and was released by the 49ers on August 7, 2015.
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People who agree with the practice maintain that it allows law enforcement to effectively combat terrorism and the drug trade. Congress would "get beat up really badly by the voters" if they interfered with law enforcement's activities.