Injuries to the likes of Harry Kane, Daniel Sturridge and Wayne Rooney have seen Southgate pluck the Manchester United striker away from Aidy Boothroyd's Under-21 squad, with the 19-year-old likely to add to his tally of six global caps.
With injuries to the likes of Harry Kane, Wayne Rooney and Daniel Sturridge, Defoe has been handed an overdue recall to the England squad to take on Germany and Lithuania this month.
Defoe is the top English scorer in the Premier League after Kane, who has 19 goals to his credit.
Southgate also warned his 26-man squad for the double-header against Germany on Wednesday and Lithuania four days later that they will not be given a day off next week.
FA bans Bournemouth's Mings for five games after Zlatan stamp
Andrew Surman ended up seeing red for pushing over Ibrahimovic and picking up his second yellow card of the game. Mings was also charged with violent conduct by the FA for landing on the Ibrahimovic's head with his studs.
"You can't always have that parachute or life-jacket of having these senior players around", Southgate told reporters at England's St George's Park headquarters in Burton-on-Trent, central England.
Wayne Rooney is no longer guaranteed a place in every England squad, manager Gareth Southgate declared on Thursday, as he painted a stark picture of the team's true global standing.
"I think it's important not to look at someone's age and dismiss them from your thinking on that".
The 34-year-old goal machine is now a crucial member of the Sunderland squad and has been in sensational form for them this season.
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Manchester United's Marcus Rashford returns to the England squad, but is he deserving of an worldwide call?
Walcott meanwhile, will still be confident of going to the 2018 World Cup even if he's bemused by Southgate's decision today.
"That is a really tough call on him and one I don't expect him to be chuffed to bits about but, as I say, I wanted to look at a couple of others".
"We've got one or two that are captaining their clubs as well and others who I think have good leadership potential", said Southgate.
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